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KMID : 1151120220300040164
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Annals of Child Neurology
2022 Volume.30 No. 4 p.164 ~ p.172
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A Mixed-Lipid Diet (Medium-Chain and Long-Chain Triglycerides) for Better Tolerability and Efficiency in Pediatric Epilepsy Patients
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Yu Ri-Ta
Lee Eun-Joo
Lee Joon-Soo
Kang Hoon-Chul
Kim Heung-Dong
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Abstract
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Purpose: In the past, the use of medium-chain triglycerides (MCTs) for a ketogenic diet (KD) was expected to improve both patients’ and caregivers’ adherence to treatment, but many gastrointestinal problems have been reported. Through a calculated partial administration of MCTs in a KD, we aimed to reduce these complications, while maintaining acceptable seizure reduction.
Methods: At a tertiary referral center for pediatric patients with epilepsy, MCT oil was given in a 1:1 ratio with long-chain triglycerides to patients on KDs. Patients who began the diet from February 2019 to February 2020 were reviewed retrospectively, and 47 patients with at least 3 months of follow-up records were enrolled in the study
Results: Overall, 29.8% of patients on a KD with an adjusted MCT ratio experienced complications, such as gastrointestinal symptoms and behavioral food refusal, compared to 63.0% of prior KD patients. The mean seizure reduction rate was 68.45%±40.61%, which was not significantly different from the comparison group’s rate of 64.84%±34.24%.
Conclusion: Adjusted MCT incorporation into a KD showed comparable seizure control results, with better tolerability of the diet.
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KEYWORD
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Diet, ketogenic, Triglycerides, Child, Drug resistant epilepsy
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